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Cell & Development Biology and Genetics- Analysis of the Schiphol Cell Complex Fire Using a Bayesian Belief Net Based Model [Stem Cell Research] Ιανουαρίου 22, 2012Publication year: 2012Source: Reliability Engineering & System Safety, Available online 20 January 2012D.M. Hanea, H.M. Jagtman, B.J.M. AleIn the night of the 26and 27October 2005, a fire broke out in the K-wing of the Schiphol Cell Complex near Amsterdam. Eleven of 43 occupants of this wing died due to smoke inhalation. The Dutch Safety Board analysed t […](author unknown)
- Quantification of Defects in composites and rubber materials using Active Thermography [Differentiation] Ιανουαρίου 22, 2012Publication year: 2012Source: Infrared Physics & Technology, Available online 21 January 2012B.B. Lahiri, S. Bagavathiappan, P.R. Reshmi, John Philip, T. Jayakumar, ...Active (lock-in and pulsed) thermography technique is used to quantify defect features in specimens of glass fiber reinforced polymer, high density rubber, low density rubber and aluminum […](author unknown)
- In vivo antidepressant activity of sesquiterpenes from the roots ofValeriana faurieiBriq [Developmental Biology] Ιανουαρίου 22, 2012Publication year: 2012Source: Fitoterapia, Available online 21 January 2012Xue Gui Liu, Pin Yi Gao, Guo Sheng Wang, Shao Jiang Song, Ling Zhi Li, ...Antidepressant activity-guided fractionation of the MeOH extract ofValeriana faurieiBriq. roots resulted in the isolation of two new germacrane-type sesquiterpenes (1–2) in addition to seven known ones (3–9). Th […](author unknown)
- Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions [Developmental Biology] Ιανουαρίου 22, 2012Publication year: 2012Source: Fitoterapia, Available online 21 January 2012Ana Paula de Vasconcellos Abdon, Greicy Coelho de Souza, Lilian Noronha Coelho de Souza, Renata Prado Vasconcelos, Carolina Araújo Castro, ...The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to exam […](author unknown)
- The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer [Seminars in Cell and Developmental Biologyγ coactivator 1 family of transcriptional coactivators in cancer] Ιανουαρίου 22, 2012Publication year: 2012Source: Seminars in Cell & Developmental Biology, Available online 21 January 2012Geoffrey D. GirnunThe critical role that altered cellular metabolism plays in promoting and maintaining the cancer phenotype has received considerable attention in recent years. For many years it was believed that aerobic glycolysis, also known as the […](author unknown)
- Analysis of the Schiphol Cell Complex Fire Using a Bayesian Belief Net Based Model [Stem Cell Research] Ιανουαρίου 22, 2012
news.yahoo » biotechnology- Gene Study Sheds Light on Body Clock's Link to Diabetes
(HealthDay)
Ιανουαρίου 31, 2012HealthDay - MONDAY, Jan. 30 (HealthDay News) -- Researchers studying the link between diabetes and a hormone that affects your so-called "body clock" have identified a genetic mutation in the receptor for the hormone, melatonin, that may to boost the risk of the disease.
- Santorum's Hypocrisy Highlighted by Daughter's Illness
(ContributorNetwork)
Ιανουαρίου 29, 2012ContributorNetwork - COMMENTARY | Republican presidential hopeful Rick Santorum suspended his bid for the GOP nod to run against Barack Obama when his daughter, Bella Santorum, was hospitalized, according to the Associated Press. Bella suffers from Trisomy 18, a rare genetic disorder in which a baby has some or all of an extra chromosome. While it is always […]
- Researchers find cancer in ancient Egyptian mummy
(AP)
Ιανουαρίου 29, 2012AP - A professor from American University in Cairo says discovery of prostate cancer in a 2,200-year-old mummy indicates the disease was caused by genetics, not environment.
- Correction: Food and Farm-GMO Labeling story
(AP)
Ιανουαρίου 27, 2012AP - In a Jan. 26 story about food labeling legislation, The Associated Press reported erroneously that Syngenta had announced plans to begin testing genetically modified wheat. Syngenta spokesman Paul Minehart said the company halted work on genetically modified wheat several years ago.
- Mutations in 2 Genes Linked to Rare Autism-Related Disorder
(HealthDay)
Ιανουαρίου 27, 2012HealthDay - THURSDAY, Jan. 26 (HealthDay News) -- Newly discovered mutations in two adjacent genes cause a rare genetic brain condition called Joubert syndrome, according to a new study.
- Gene Study Sheds Light on Body Clock's Link to Diabetes
(HealthDay)
Ιανουαρίου 31, 2012
Περιοδικό » BMC Biology- A novel role for microglia in minimizing excitotoxicityMicroglia are the abundant, resident myeloid cells of the central nervous system (CNS) that become rapidly activated in response to injury or inflammation. While most studies of microglia focus on this phenomenon, little is known about the function of 'resting' microglia, which possess fine, branching cellular processes. Biber and colleagues, in a […]Ben Barres
- Q&A: What is a pathogen? A question that begs the point{No abstract}Arturo Casadevall
- Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathwayBackground: Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates. The kinase plays important role in a number of cellular processes. The cellular functions of Plasmodium falciparum protein kinase CK2 (PfCK2) are unknown. The parasite's genome encodes one catalytic subunit, PfCK2, which we have previous […]Christian Doerig
- Single vesicle imaging indicates distinct modes of rapid membrane retrieval during nerve growthBackground: During nerve growth, cytoplasmic vesicles add new membrane preferentially to the growth cone located at the distal tip of extending axons. Growth cone membrane is also retrieved locally, and asymmetric retrieval facilitates membrane remodeling during growth cone repulsion by a chemorepellent gradient. Moreover, growth inhibitory factors can stimu […]John Henley
- Global transgenerational gene expression dynamics in two newly synthesized allohexaploid wheat (Triticum aestivum) linesBackground: Alteration in gene expression resulting from allopolyploidization is a prominent feature in plants, but its spectrum and extent are not fully known. Common wheat (Triticum aestivum) was formed via allohexaploidization about 10,000 years ago, and became the most important crop plant. To gain further insights into the genome-wide transcriptional dy […]Bao Liu
- Protein dynamics and conformational selection in bidirectional signal transduction Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous ensemble and loop dynamics explain how the […]Buyong Ma
- Detailed interrogation of trypanosome cell biology via
differential organelle staining and automated image analysisBackground: Many trypanosomatid protozoa are important human or animal pathogens. The well-defined morphology and precisely choreographed division of trypanosomatid cells makes morphological analysis a powerful tool for analysing the effect of mutations, chemical insults and changes between lifecycle stages. High throughput image analysis of micrographs has […]Eva Gluenz
- Difficult phylogenetic questions: more data, maybe; better methods, certainly
Contradicting the prejudice that endosymbiosis is a rare phenomenon, Husník and co-workers show in BMC Biology that bacterial endosymbiosis has occured several times independently during insect evolution. Rigorous phylogenetic analyses, in particular using complex models of sequence evolution and an original site removal procedure, allow this conclusion to b […]Beatrice Roure
- The bending of cell sheets - from folding to rollingThe bending of cell sheets plays a major role in multicellular embryonic morphogenesis. Recent advances are leading to a deeper understanding of how the biophysical properties and the force-producing behaviors of cells are regulated, and how these forces are integrated across cell sheets during bending. We review work that shows that the dynamic balance of a […]David Shook
- There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globatorBackground: Epithelial folding is a common morphogenetic process during the development of multicellular organisms. In metazoans, the biological and biomechanical processes that underlie such three-dimensional (3D) developmental events are usually complex and difficult to investigate. Spheroidal green algae of the genus Volvox are uniquely suited as model sy […]Armin Hallmann
- A novel role for microglia in minimizing excitotoxicity
Περιοδικό » American Journal of Human Genetics- The Arabian Cradle: Mitochondrial Relicts of the First Steps along the Southern Route out of Africa Ιανουαρίου 27, 2012Publication year: 2012Source: The American Journal of Human Genetics, Available online 26 January 2012Verónica Fernandes, Farida Alshamali, Marco Alves, Marta D. Costa, Joana B. Pereira, ...A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first human steps outside of Africa. The “sout […]
- Lack of the Mitochondrial Protein Acylglycerol Kinase Causes Sengers Syndrome Ιανουαρίου 27, 2012Publication year: 2012Source: The American Journal of Human Genetics, Available online 26 January 2012Johannes A. Mayr, Tobias B. Haack, Elisabeth Graf, Franz A. Zimmermann, Thomas Wieland, ...Exome sequencing of an individual with congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, and lactic acidosis, all typical symptoms of Sengers syndr […]
- X-Linked Megalocornea Caused by Mutations inCHRDL1Identifies an Essential Role for Ventroptin in Anterior Segment Development Ιανουαρίου 27, 2012Publication year: 2012Source: The American Journal of Human Genetics, Available online 26 January 2012Tom R. Webb, Mar Matarin, Jessica C. Gardner, Dan Kelberman, Hala Hassan, ...X-linked megalocornea (MGC1) is an ocular anterior segment disorder characterized by an increased cornea diameter and deep anterior chamber evident at birth and later onset of mosai […]
- Mutations inKIF11Cause Autosomal-Dominant Microcephaly Variably Associated with Congenital Lymphedema and Chorioretinopathy Ιανουαρίου 27, 2012Publication year: 2012Source: The American Journal of Human Genetics, Available online 26 January 2012Pia Ostergaard, Michael A. Simpson, Antonella Mendola, Pradeep Vasudevan, Fiona C. Connell, ...We have identifiedKIF11mutations in individuals with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy. Initial whole-e […]
- Mitochondrial DNA and Y Chromosome Variation Provides Evidence for a Recent Common Ancestry between Native Americans and Indigenous Altaians Ιανουαρίου 27, 2012Publication year: 2012Source: The American Journal of Human Genetics, Available online 25 January 2012Matthew C. Dulik, Sergey I. Zhadanov, Ludmila P. Osipova, Ayken Askapuli, Lydia Gau, ...The Altai region of southern Siberia has played a critical role in the peopling of northern Asia as an entry point into Siberia and a possible homeland for ancestral Nati […]
- The Arabian Cradle: Mitochondrial Relicts of the First Steps along the Southern Route out of Africa Ιανουαρίου 27, 2012
Περιοδικό » Cell- Critical Role of Amyloid-like Oligomers ofDrosophilaOrb2 in the Persistence of Memory Ιανουαρίου 27, 2012Publication year: 2012Source: Cell, Available online 26 January 2012Amitabha Majumdar, Wanda Colón Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, ...A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days. Previously, we po […]
- In This Issue Ιανουαρίου 20, 2012Publication year: 2012Source: Cell, Volume 148, Issues 1–2, 20 January 2012, Pages 1[No author name available]
- Stem Cell Frontiers Ιανουαρίου 20, 2012Publication year: 2012Source: Cell, Volume 148, Issues 1–2, 20 January 2012, Pages 9[No author name available] 2011 was a blockbuster year for the stem cell field. Researchers made great progress in growing complex organs in vitro and producing a variety of cell types on demand. But in the last few months, a few studies have markedly propelled the field forw […]
- Bursting with Exciting Biology Ιανουαρίου 20, 2012Publication year: 2012Source: Cell, Volume 148, Issues 1–2, 20 January 2012, Pages 13TheCelleditorial team:, Emilie, Elena, Robert, Karen, ...
- Funding in 2012: “Great Recession” Starts to Bite Ιανουαρίου 20, 2012Publication year: 2012Source: Cell, Volume 148, Issues 1–2, 20 January 2012, Pages 14-16Colin MacilwainBiomedical research budgets are frozen or falling in developed countries. Can expansion in developing nations continue as economic contagion spreads?
- Critical Role of Amyloid-like Oligomers ofDrosophilaOrb2 in the Persistence of Memory Ιανουαρίου 27, 2012
Περιοδικό » Current Opinion in Biotechnology- Improving yield by exploiting mechanisms underlying natural variation of photosynthesis Ιανουαρίου 30, 2012Publication year: 2012Source: Current Opinion in Biotechnology, Available online 30 January 2012Tracy Lawson, David M Kramer, Christine A RainesIncreasing photosynthesis in C3 species has been identified as an approach to increase the yield of crop plants. Most of our knowledge of photosynthetic performance has come from studies in which plants were grown in […]
- Synthetic signaling networks for therapeutic applications Ιανουαρίου 29, 2012Publication year: 2012Source: Current Opinion in Biotechnology, Available online 27 January 2012T Chris Aurand, Matthew S Russell, John C MarchSynthetic signaling networks contain exogenous, modified, or rationally designed components involved in sending, receiving, and processing information from the environment and other cells. Advances in the input, outpu […]
- Innovation at the intersection of synthetic and systems biology Ιανουαρίου 20, 2012Publication year: 2012Source: Current Opinion in Biotechnology, Available online 19 January 2012Amanda M Lanza, Nathan C Crook, Hal S AlperThe promises of modern biotechnology hinge upon the hope that we can understand microscopic cellular complexity and in doing so create novel function. In this regard, the fields of systems and synthetic biology are import […]
- New and emerging analytical techniques for marine biotechnology Ιανουαρίου 20, 2012Publication year: 2012Source: Current Opinion in Biotechnology, Available online 19 January 2012J Grant BurgessMarine biotechnology is the industrial, medical or environmental application of biological resources from the sea. Since the marine environment is the most biologically and chemically diverse habitat on the planet, marine biotechnology has, in recen […]
- Re-engineering of carbon fixation in plants – challenges for plant biotechnology to improve yields in a high-CO2world Ιανουαρίου 18, 2012Publication year: 2012Source: Current Opinion in Biotechnology, Available online 17 January 2012Christoph Peterhansel, Sascha OffermannSource and sink strength control plant carbon gain and yield. Source strength was recently engineered by modifying the large subunit of Rubisco, replacing the small subunit, and creating improved thermostable Rubisco activase […]
- Improving yield by exploiting mechanisms underlying natural variation of photosynthesis Ιανουαρίου 30, 2012
Περιοδικό » Current Opinion in Cell Biology- Local signaling within stem cell niches: insights fromDrosophila Ιανουαρίου 30, 2012Publication year: 2012Source: Current Opinion in Cell Biology, Available online 30 January 2012Luís Pedro F Resende, D Leanne JonesTissue stem cells are found in specialized microenvironments (niches) where they are exposed to diverse systemic and local signals that are integrated with cell intrinsic factors to regulate stem cell behavior. In general, system […]
- From stem cells to cancer stem cells: HIF takes the stage Ιανουαρίου 30, 2012Publication year: 2012Source: Current Opinion in Cell Biology, Available online 30 January 2012Kyoung Eun Lee, M Celeste SimonHypoxia, a condition of insufficient oxygen availability, occurs during normal development as well as tumorigenesis. Cellular responses to hypoxia are primarily mediated by hypoxia-inducible factors (HIFs). Recent studies have reveale […]
- Cilia, KIF3 molecular motor and nodal flow Ιανουαρίου 29, 2012Publication year: 2012Source: Current Opinion in Cell Biology, Available online 27 January 2012Nobutaka Hirokawa, Yosuke Tanaka, Yasushi OkadaThe establishment of left–right asymmetry during development of vertebrate embryos depends on leftward flow in the nodal cavity. The flow is produced by the rotational movement of the posteriorly tilted nodal cilia. Ho […]
- Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer Ιανουαρίου 27, 2012Publication year: 2012Source: Current Opinion in Cell Biology, Available online 26 January 2012Shannon K Hughes-Alford, Douglas A LauffenburgerChemotaxis of tumor cells in response to a gradient of extracellular ligand is an important step in cancer metastasis. The heterogeneity of chemotactic responses in cancer has not been widely addressed by experimental […]
- An Intracellular Transmission Control Protocol: assembly and transport of ribonucleoprotein complexes Ιανουαρίου 25, 2012Publication year: 2012Source: Current Opinion in Cell Biology, Available online 23 January 2012Virginie Marchand, Imre Gaspar, Anne EphrussiInitially assumed to be a special feature of highly polarized eukaryotic cells, recent evidence suggests that mRNA localization coupled with local translation is a widespread strategy for spatial restriction of protein s […]
- Local signaling within stem cell niches: insights fromDrosophila Ιανουαρίου 30, 2012
Περιοδικό » Current Opinion in Genetics & Development- Polyglutamine neurodegeneration: expanded glutamines enhance native functions Ιανουαρίου 27, 2012Publication year: 2012Source: Current Opinion in Genetics & Development, Available online 25 January 2012Harry T OrrAn intriguing set of neurodegenerative disease are the nine disorders caused by the expansion of a unstable trinucleotide CAG repeat where the repeat is located within the coding of the affected gene, that is, the polyglutamine (polyQ) dise […]
- Nuclear architecture by RNA Ιανουαρίου 27, 2012Publication year: 2012Source: Current Opinion in Genetics & Development, Available online 24 January 2012Maïwen Caudron-Herger, Karsten RippeThe dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important determinant of cell function. Recent studies point to a crucial role of RNA as an archite […]
- Nuclear architecture by RNA Ιανουαρίου 25, 2012Publication year: 2012Source: Current Opinion in Genetics & Development, Available online 24 January 2012Maïwen Caudron-Herger, Karsten RippeThe dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important determinant of cell function. Recent studies point to a crucial role of RNA as an archite […]
- Cancer gene discovery in the mouse Ιανουαρίου 22, 2012Publication year: 2012Source: Current Opinion in Genetics & Development, Available online 20 January 2012Rebecca E McIntyre, Louise van der Weyden, David J AdamsDevelopments in high-throughput genome analysis and in computational tools have made it possible to rapidly profile entire cancer genomes with basepair resolution. In parallel with these advances […]
- Cancer gene discovery in the mouse Ιανουαρίου 20, 2012Publication year: 2012Source: Current Opinion in Genetics & Development, Available online 20 January 2012Rebecca E McIntyre, Louise van der Weyden, David J AdamsDevelopments in high-throughput genome analysis and in computational tools have made it possible to rapidly profile entire cancer genomes with basepair resolution. In parallel with these advances […]
- Polyglutamine neurodegeneration: expanded glutamines enhance native functions Ιανουαρίου 27, 2012
Περιοδικό » Genomics- Multiplex PCR-based Alu insertion polymorphisms genotyping for identifying individuals of Japanese ethnicity Ιανουαρίου 27, 2012Publication year: 2012Source: Genomics, Available online 25 January 2012Masaru Asari, Tomohiro Omura, Kumiko Oka, Chikatoshi Maseda, Yoshikazu Tasaki, ...Discrimination of Alu insertions is a useful tool for geographic ancestry analysis, and is usually performed by Alu element amplification and agarose gel electrophoresis. Here, we have developed a new fluor […]
- Whole-exome sequencing in a single proband reveals a mutation in theCHST8gene in autosomal recessive peeling skin syndrome Ιανουαρίου 27, 2012Publication year: 2012Source: Genomics, Available online 25 January 2012Rita M. Cabral, Mazen Kurban, Muhammad Wajid, Yutaka Shimomura, Lynn Petukhova, ...Generalized peeling skin syndrome (PSS) is an autosomal recessive genodermatosis characterized by lifelong, continuous shedding of the upper epidermis. Using whole-genome homozygozity mapping and whole-exo […]
- Comparative genomic analysis of two brucellaphages of distant origins Ιανουαρίου 22, 2012Publication year: 2012Source: Genomics, Available online 21 January 2012Victor Flores, Ahidé López-Merino, Guillermo Mendoza-Hernandez, Gabriel GuarnerosHere, we present the first complete genome sequence of brucellaphage Tbilisi (Tb) and compared it with that of Pr, a broad host-range brucellaphage recently isolated in Mexico. The genomes consist of 41,148 […]
- Development of TaqMan allelic discrimination based genotyping of large DNA deletions Ιανουαρίου 19, 2012Publication year: 2012Source: Genomics, Available online 17 January 2012Anastasia Fedick, Jing Su, Nathan R. TreffThe high prevalence of genetic diseases resulting from gross deletions has highlighted a need for a quick, simple, and reliable method of genotyping these mutations. Here, we developed a novel strategy for applying TaqMan allelic discrimination t […]
- Development of TaqMan allelic discrimination based genotyping of large DNA deletions Ιανουαρίου 18, 2012Publication year: 2012Source: Genomics, Available online 17 January 2012Anastasia Fedick, Jing Su, Nathan R. TreffThe high prevalence of genetic diseases resulting from gross deletions has highlighted a need for a quick, simple, and reliable method of genotyping these mutations. Here, we developed a novel strategy for applying TaqMan allelic discrimination t […]
- Multiplex PCR-based Alu insertion polymorphisms genotyping for identifying individuals of Japanese ethnicity Ιανουαρίου 27, 2012
Περιοδικό » Journal of Clinical Investigation-
Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. Neural derivatives of human embryonic stem cells (hESCs) are currently being used for cell therapy in 3 clinical trials. However, hESCs are prone to genomic instability, which could limit their clinical utility. Here, we report that neural differentiation of hESCs syste […]Christine Varela, Jérôme Alexandre Denis, Jérôme Polentes, Maxime Feyeux, Sophie Aubert, Benoite Champon, Geneviève Piétu, Marc Peschanski, Nathalie Lefort
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Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice
A complex biologic network regulates kidney perfusion under physiologic conditions. This system is profoundly perturbed following renal ischemia, a leading cause of acute kidney injury (AKI) — a life-threatening condition that frequently complicates the care of hospitalized patients. Therapeutic approaches to prevent and treat AKI are extremely limite […]Almut Grenz, Jessica D. Bauerle, Julee H. Dalton, Douglas Ridyard, Alexander Badulak, Eunyoung Tak, Eóin N. McNamee, Eric Clambey, Radu Moldovan, German Reyes, Jost Klawitter, Kelly Ambler, Kristann Magee, Uwe Christians, Kelley S. Brodsky, Katya Ravid, Doo-Sup Choi, Jiaming Wen, Dmitriy Lukashev, Michael R. Blackburn, Hartmut Osswald, Imogen R. Coe, Bernd Nürnberg, Volker H. Haase, Yang Xia, Michail Sitkovsky, Holger K. Eltzschig
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Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
Brown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence in adult humans and its contribution to human metabolism were thought to be minimal or insignificant. Recent studies using PET with 18F-fluorodeoxyglucose (18FDG) have shown the presence of BAT in adult humans. However, whether BAT co […]Véronique Ouellet, Sébastien M. Labbé, Denis P. Blondin, Serge Phoenix, Brigitte Guérin, François Haman, Eric E. Turcotte, Denis Richard, André C. Carpentier
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Yes, even human brown fat is on fire!
That adult humans possess brown fat is now accepted — but is the brown fat metabolically active? Does human brown fat actually combust fat to release heat? In this issue of the JCI, Ouellet et al. demonstrate that metabolism in brown fat really is increased when adult humans are exposed to cold. This boosts the possibility that calorie combustion in b […]Barbara Cannon, Jan Nedergaard
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Preserving postischemic reperfusion in the kidney: a role for extracellular adenosine
Several adenosine receptor subtypes on endothelial, epithelial, mesangial, and inflammatory cells have been implicated in ischemic acute kidney injury, a life-threatening condition that frequently complicates the care of hospitalized patients. In this issue of the JCI, Grenz and coworkers provide novel insight into how preservation of postischemic renal perf […]Joel M. Weinberg, Manjeri A. Venkatachalam
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Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
Περιοδικό » Journal of Molecular Biology- Editorial Board Ιανουαρίου 30, 2012Publication year: 2012Source: Journal of Molecular Biology, Volume 416, Issue 1, 10 February 2012, Pages i[No author name available]
- Contents Ιανουαρίου 30, 2012Publication year: 2012Source: Journal of Molecular Biology, Volume 416, Issue 1, 10 February 2012, Pages iii-iv[No author name available]
- Crystal Structure ofPseudomonas AeruginosaTsi2 Reveals a Stably Folded Superhelical Antitoxin Ιανουαρίου 30, 2012Publication year: 2012Source: Journal of Molecular Biology, Available online 30 January 2012Ting Ting Zou, Xue Yao, Bo Qin, Meng Zhang, Li Feng Cai, ...In the competition for niches in natural resource,Pseudomonas Aeruginosautilizes the type VI secretion system to inject toxic protein effector Tse2 into the cell-cell contacted bacteria. The cytoplasm toxin i […]
- Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9 Ιανουαρίου 30, 2012Publication year: 2012Source: Journal of Molecular Biology, Available online 30 January 2012Grigorios Papadakos, Nicholas G. Housden, Katie J. Lilly, Renata Kaminska, Colin KleanthousTolB and Pal are members of the Tol-Pal system that spans the cell envelope of Gram-negative bacteria and contributes to the stability and integrity of the bacterial outer membr […]
- The transition state of coupled folding and binding for a flexible β-finger Ιανουαρίου 30, 2012Publication year: 2012Source: Journal of Molecular Biology, Available online 30 January 2012O. Andreas Karlsson, Celestine N. Chi, Åke Engström, Per JemthFlexible as well as fully disordered protein regions that fold upon binding, mediate numerous protein-protein interactions. However, little is known about their mechanism of interaction. One such coupled fo […]
- Editorial Board Ιανουαρίου 30, 2012
Περιοδικό » Journal of Structural and Functional Genomics- Enhancement of crystallization with nucleotide ligands identified by dye-ligand affinity chromatography Ιανουαρίου 27, 2012
- Structure- and sequence-based function prediction for non-homologous proteins Ιανουαρίου 24, 2012
- KB-Rank: efficient protein structure and functional annotation identification via text query Ιανουαρίου 24, 2012
- Canadian macromolecular crystallography facility: a suite of fully automated beamlines Ιανουαρίου 24, 2012
- Solution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771 Ιανουαρίου 5, 2012
Περιοδικό » Nature- Access all areasTo create a sustainable, open research literature, governments need to find the finances to make it viable — and recognize that adding value to diversifying research outputs has its own costs.
- Fertile unionScientists and politicians are working together to bring new reproductive techniques to Britain.
- Notes on screenComputer tablets are changing the way that scientists record their experiments.
- Cultural history holds back Chinese researchConfucius and Zhuang have produced a culture in China that values isolation and inhibits curiosity. Neither is good for science, says Peng Gong.Peng Gong
- Animal behaviour: Snakes strangle with feelingAs boa constrictors tighten their bodies around their prey, the snakes sense the dying animal's heart rate to determine how much pressure to apply and when to stop squeezing.Scott Boback and his colleagues at Dickinson College in Carlisle, Pennsylvania, implanted simulated hearts into warm,
- Access all areas
Περιοδικό » PLoS Biology- Reconstructing Speech from Human Auditory Cortex Ιανουαρίου 31, 2012by Brian N. Pasley, Stephen V. David, Nima Mesgarani, Adeen Flinker, Shihab A. Shamma, Nathan E. Crone, Robert T. Knight, Edward F. Chang How the human auditory system extracts perceptually relevant acoustic features of speech is unknown. To address this question, we used intracranial recordings from nonprimary auditory cortex in the human superior temporal […]Brian N. Pasley et al.
- Pulsed Feedback Defers Cellular Differentiation Ιανουαρίου 31, 2012by Joe H. Levine, Michelle E. Fontes, Jonathan Dworkin, Michael B. Elowitz Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a defer […]Joe H. Levine et al.
- Desperately Seeking Stable 50-Year-Old Landscapes with Patches and Long, Wide Corridors Ιανουαρίου 31, 2012by Paul Beier, Andrew J. GregoryPaul Beier et al.
- Built-in Timer Delays Differentiation Ιανουαρίου 31, 2012by Liza GrossLiza Gross
- Stochastic Expression of the Interferon-β Gene Ιανουαρίου 24, 2012by Mingwei Zhao, Jiangwen Zhang, Hemali Phatnani, Stefanie Scheu, Tom Maniatis Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. Previous studies have shown that only a fraction of the infected cells produce IFN. However, the mechanis […]Mingwei Zhao et al.
- Structural and Functional Loss in Restored Wetland Ecosystems Ιανουαρίου 24, 2012by David Moreno-Mateos, Mary E. Power, Francisco A. Comín, Roxana Yockteng Wetlands are among the most productive and economically valuable ecosystems in the world. However, because of human activities, over half of the wetland ecosystems existing in North America, Europe, Australia, and China in the early 20th century have been lost. Ecological restoration […]David Moreno-Mateos et al.
- Restoration of Ailing Wetlands Ιανουαρίου 24, 2012by Oswald J. Schmitz It is widely held that humankind's destructive tendencies when exploiting natural resources leads to irreparable harm to the environment. Yet, this thinking runs counter to evidence that many ecological systems damaged by severe natural environmental disturbances (e.g., hurricanes) can restore themselves via processes of natural rec […]Oswald J. Schmitz
- The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres Ιανουαρίου 24, 2012by Mar Carmena, Xavier Pinson, Melpi Platani, Zeina Salloum, Zhenjie Xu, Anthony Clark, Fiona MacIsaac, Hiromi Ogawa, Ulrike Eggert, David M. Glover, Vincent Archambault, William C. Earnshaw The coordinated activities at centromeres of two key cell cycle kinases, Polo and Aurora B, are critical for ensuring that the two sister kinetochores of each chromosome […]Mar Carmena et al.
- Rapid Evolution of Enormous, Multichromosomal Genomes in Flowering Plant Mitochondria with Exceptionally High Mutation Rates Ιανουαρίου 17, 2012by Daniel B. Sloan, Andrew J. Alverson, John P. Chuckalovcak, Martin Wu, David E. McCauley, Jeffrey D. Palmer, Douglas R. Taylor Genome size and complexity vary tremendously among eukaryotic species and their organelles. Comparisons across deeply divergent eukaryotic lineages have suggested that variation in mutation rates may explain this diversity, with in […]Daniel B. Sloan et al.
- Substrate Specificity within a Family of Outer Membrane Carboxylate Channels Ιανουαρίου 17, 2012by Elif Eren, Jagamya Vijayaraghavan, Jiaming Liu, Belete R. Cheneke, Debra S. Touw, Bryan W. Lepore, Mridhu Indic, Liviu Movileanu, Bert van den Berg Many Gram-negative bacteria, including human pathogens such as Pseudomonas aeruginosa, do not have large-channel porins. This results in an outer membrane (OM) that is highly impermeable to small polar molecul […]Elif Eren et al.
- Reconstructing Speech from Human Auditory Cortex Ιανουαρίου 31, 2012
Περιοδικό » PLoS Genetics- A Flexible Bayesian Model for Studying Gene–Environment Interaction Ιανουαρίου 26, 2012by Kai Yu, Sholom Wacholder, William Wheeler, Zhaoming Wang, Neil Caporaso, Maria Teresa Landi, Faming Liang An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influenc […]Kai Yu et al.
- A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese Ιανουαρίου 26, 2012by Yukinori Okada, Kenichi Shimane, Yuta Kochi, Tomoko Tahira, Akari Suzuki, Koichiro Higasa, Atsushi Takahashi, Tetsuya Horita, Tatsuya Atsumi, Tomonori Ishii, Akiko Okamoto, Keishi Fujio, Michito Hirakata, Hirofumi Amano, Yuya Kondo, Satoshi Ito, Kazuki Takada, Akio Mimori, Kazuyoshi Saito, Makoto Kamachi, Yasushi Kawaguchi, Katsunori Ikari, Osman Wael Moh […]Yukinori Okada et al.
- Inference of Population Structure using Dense Haplotype Data Ιανουαρίου 26, 2012by Daniel John Lawson, Garrett Hellenthal, Simon Myers, Daniel Falush The advent of genome-wide dense variation data provides an opportunity to investigate ancestry in unprecedented detail, but presents new statistical challenges. We propose a novel inference framework that aims to efficiently capture information on population structure provided by patterns […]Daniel John Lawson et al.
- Two-Component Elements Mediate Interactions between Cytokinin and Salicylic Acid in Plant Immunity Ιανουαρίου 26, 2012by Cristiana T. Argueso, Fernando J. Ferreira, Petra Epple, Jennifer P. C. To, Claire E. Hutchison, G. Eric Schaller, Jeffery L. Dangl, Joseph J. Kieber Recent studies have revealed an important role for hormones in plant immunity. We are now beginning to understand the contribution of crosstalk among different hormone signaling networks to the outcome of pl […]Cristiana T. Argueso et al.
- Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis Ιανουαρίου 26, 2012by Kimberly Larson, Shian-Jang Yan, Amy Tsurumi, Jacqueline Liu, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H. Eickbush, Willis X. Li Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been contr […]Kimberly Larson et al.
- High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency Ιανουαρίου 26, 2012by Ricardo C. Ferreira, Qiang Pan-Hammarström, Robert R. Graham, Gumersindo Fontán, Annette T. Lee, Ward Ortmann, Ning Wang, Elena Urcelay, Miguel Fernández-Arquero, Concepción Núñez, Gudmundur Jorgensen, Björn R. Ludviksson, Sinikka Koskinen, Katri Haimila, Leonid Padyukov, Peter K. Gregersen, Lennart Hammarström, Timothy W. Behrens Selective IgA deficiency […]Ricardo C. Ferreira et al.
- Sequencing of Pooled DNA Samples (Pool-Seq) Uncovers Complex Dynamics of Transposable Element Insertions in Drosophila melanogaster Ιανουαρίου 26, 2012by Robert Kofler, Andrea J. Betancourt, Christian Schlötterer Transposable elements (TEs) are mobile genetic elements that parasitize genomes by semi-autonomously increasing their own copy number within the host genome. While TEs are important for genome evolution, appropriate methods for performing unbiased genome-wide surveys of TE variation in natural pop […]Robert Kofler et al.
- Reduced Lentivirus Susceptibility in Sheep with TMEM154 Mutations Ιανουαρίου 26, 2012by Michael P. Heaton, Michael L. Clawson, Carol G. Chitko-Mckown, Kreg A. Leymaster, Timothy P. L. Smith, Gregory P. Harhay, Stephen N. White, Lynn M. Herrmann-Hoesing, Michelle R. Mousel, Gregory S. Lewis, Theodore S. Kalbfleisch, James E. Keen, William W. Laegreid Visna/Maedi, or ovine progressive pneumonia (OPP) as it is known in the United States, is an […]Michael P. Heaton et al.
- USF-1 Is Critical for Maintaining Genome Integrity in Response to UV-Induced DNA Photolesions Ιανουαρίου 26, 2012by Yorann Baron, Sébastien Corre, Nicolas Mouchet, Sophie Vaulont, Sharon Prince, Marie-Dominique Galibert An important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This is an extremely challenging task since the cell's DNA is constantly under assault by endogenous and environmental […]Yorann Baron et al.
- A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation Ιανουαρίου 26, 2012by Silvia Naitza, Eleonora Porcu, Maristella Steri, Dennis D. Taub, Antonella Mulas, Xiang Xiao, James Strait, Mariano Dei, Sandra Lai, Fabio Busonero, Andrea Maschio, Gianluca Usala, Magdalena Zoledziewska, Carlo Sidore, Ilenia Zara, Maristella Pitzalis, Alessia Loi, Francesca Virdis, Roberta Piras, Francesca Deidda, Michael B. Whalen, Laura Crisponi, Anton […]Silvia Naitza et al.
- A Flexible Bayesian Model for Studying Gene–Environment Interaction Ιανουαρίου 26, 2012
Περιοδικό » Sciencemag- The Secret of Dino Success Φεβρουαρίου 1, 2012Creatures didn't dominate Earth by decimating their competition
- ScienceShot: Cowardly Spider Can Inseminate Female From Afar Φεβρουαρίου 1, 2012Male's broken genitalia transfers sperm into cannibalistic female after he's fled
- ScienceShot: Distracted Female Fish Lose Weight Φεβρουαρίου 1, 2012Gaudy tails in male splitfins are bad news for female foragers
- ScienceShot: A Brain Wave Worth a Thousand Words Ιανουαρίου 31, 2012Computer program reconstructs what a person hears based on brain activity alone
- Rap Music Powers Health Device Ιανουαρίου 31, 2012A little Jay-Z each day could keep the doctor away
- The Secret of Dino Success Φεβρουαρίου 1, 2012
Περιοδικό » Science Magazine- [News of the Week] Around the WorldIn science news around the world this week, outbreaks of H5N1 continue in poultry in south and southeast Asia—and the human death toll mounts; the University of Tokyo plans to shift the start of its school year from April to autumn; researchers are looking for signs of life in the Tissint meteorites; the Natural History Museum in London is under fire for its […]
- [News of the Week] Random SamplePeerage of Science, an online social network founded by three Finnish ecologists, aims to provide journals with already-peer-reviewed manuscripts. And this week's numbers quantify NIH grant success rates and the number of bats that have died from white nose syndrome.
- [News of the Week] NewsmakersThis week's Newsmakers are Terence Tao of the University of California, Los Angeles (UCLA), and Jean Bourgain of the Institute for Advanced Study, winners of the Crafoord Prize in mathematics; Reinhard Genzel of the Max Planck Institute for Extraterrestrial Physics and Andrea Ghez of UCLA, who will claim the prize for astronomy; and Cristián Samper, who […]
- [News & Analysis] H5N1: Flu Controversy Spurs Research MoratoriumAmid a growing global controversy over the potential dangers of experiments involving the H5N1 avian influenza virus, a group of leading influenza researchers last week agreed to a 60-day moratorium on some sensitive flu studies.Author: David MalakoffDavid Malakoff
- [News & Analysis] H5N1: Ron Fouchier: In the Eye of the StormScience talked to Ron Fouchier of Erasmus MC in Rotterdam, the Netherlands, who carried out one of the two controversial H5N1 avian influenza studies that triggered the international debate.Author: Martin EnserinkMartin Enserink
- [News of the Week] Around the World
Περιοδικό » ScientificAmerican- Word-of-Mind: Researchers Decode Words from the Brain's Auditory Activity Ιανουαρίου 31, 2012Oh, to be a fly on the auditory cortex! [More]
- Volcanoes May Have Sparked Little Ice Age Ιανουαρίου 31, 2012A mysterious, centuries-long cool spell, dubbed the Little Ice Age, appears to have been caused by a series of volcanic eruptions and sustained by sea ice, a new study indicates. [More]
- Gigantic Radio Telescope to Search for First Stars and Galaxies Ιανουαρίου 31, 2012More than 20,000 radio antennas will soon connect over the Internet to scan largely unexplored radio frequencies, hunting for the first stars and galaxies and potentially signals of extraterrestrial intelligence. [More]
- Did Leonardo da Vinci Copy His Famous "Vitruvian Man"? Ιανουαρίου 31, 2012Leonardo da Vinci 's drawing of a male figure perfectly inscribed in a circle and square, known as the "Vitruvian Man," illustrates what he believed to be a divine connection between the human form and the universe. Beloved for its beauty and symbolic power, it is one of the most famous images in the world. However, new research suggests that […]
- Marijuana Mouth Spray: Will Cancer Pain Reliever Be Abused? Ιανουαρίου 31, 2012The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say. [More]
- Word-of-Mind: Researchers Decode Words from the Brain's Auditory Activity Ιανουαρίου 31, 2012
Περιοδικό » The Lancet- [This Week in Medicine] January 28–February 3, 2012At the end of 2011, China's urban population overtook its rural population for the first time. The National Bureau of Statistics reports that 51·3% of the country's 1·35 billion people now live in cities. For an economy at China's stage of development, this ratio is still low, possibly due to past constraints on free movement.The Lancet
- [Editorial] Neurological diseases remain neglected and ignoredIn this week's Perspectives section, Hilary and Steven Rose describe the moving film Playing Against Time. This film describes the life and music of Barbara Thompson, a jazz saxophonist, and her efforts to continue with her music despite the diagnosis of Parkinson's disease in 1996, including her struggle to obtain care and treatment. The diagnosis […]The Lancet
- [Editorial] Tobacco in the USA: smoke and mirrorsIn an episode of the science fiction series Star Trek: Deep Space Nine, a trio of capitalist aliens find themselves thrown back in time to 1947. They are overjoyed to discover human beings—including medical staff—smoking tobacco. “If they'll buy poison, they'll buy anything!” cackles one of the protagonists, smelling a profit.The Lancet
- [Editorial] The Research Works Act: a damaging threat to science“Academic publishers have become the enemies of science.” So wrote Dr Mike Taylor, a scientist at the UK's University of Bristol. He, and many scientists like him, are angry that publishers are supporting the Research Works Act (RWA), a controversial Bill before the US Congress.The Lancet
- [Comment] Optimisation of mass chemotherapy to control soil-transmitted helminth infectionLeaders from international agencies, including WHO and the World Bank, charities, and pharmaceutical companies, together with politicians from donor and recipient countries, will meet in London on Jan 30, 2012, to pledge increased support and collaboration for the control of neglected tropical diseases (NTDs). A London Declaration from this meeting will mark […]Roy Anderson, T Deirdre Hollingsworth, James Truscott, Simon Brooker
- [Comment] Adjuvant therapy for gastric cancer after D2 gastrectomyAlthough adjuvant therapy for gastric cancer is known to improve prognosis, controversies remain about the choice of chemotherapeutic regimens, the use of radiation therapy, and the selection of patients who are likely to benefit from different therapies. Adjuvant therapy is used to eradicate potential micrometastases after curative surgery and, therefore, t […]Toshirou Nishida
- [Comment] Vitamin K antagonists: self-determination by self-monitoring?Vitamin K antagonists have been successfully used for more than 50 years as oral anticoagulant drugs in patients at risk of venous or arterial thromboembolism. Because of a narrow therapeutic window and an unpredictable dose response, regular laboratory monitoring is mandatory. A strong association exists between the intensity of anticoagulation and adverse […]Paul Alexander Kyrle, Sabine Eichinger
- [Comment] Neonatal screening for lysosomal storage disordersLysosomal storage disorders are a diverse group of more than 50 serious, progressive diseases. Until recently, treatment was symptomatic with the expected outcomes of great disability and premature death. Improvements in bone-marrow transplantation and development of recombinant enzyme replacement therapies for some of these disorders have raised the expecta […]Janice Fletcher, Bridget Wilcken
- [Comment] Oral azithromycin for treatment of yawsYaws—an infectious disease caused by Treponema pallidum subsp pertenue—affects children and adults in poor rural communities in tropical countries, causing disfiguring lesions of the skin and bones. The yaws elimination programme coordinated by WHO in the 1950s and 1960s screened more than 160 million people, treated more than 50 million people with intramus […]David Mabey
- [Comment] Respiratory medicine: a call for research papersWe invite you to submit your best research in respiratory medicine for our annual respiratory theme issue, which will be published to coincide with the 2012 European Respiratory Society (ERS) conference in Vienna, Austria on Sept 1–5.Sabine Kleinert
- [This Week in Medicine] January 28–February 3, 2012
Περιοδικό » The Scientist- The rhythm of biology Ιουνίου 3, 2011An art exhibit in New York City explores the science behind our reaction to soundsBob Grant
- XMRV doesn't cause chronic fatigue Ιουνίου 3, 2011Two studies point to contamination of patient samples as the cause of a controversial 2009 finding that linked the mouse virus XMRV with chronic fatigue syndromeTia Ghose
- Speaking of science Ιουνίου 3, 2011See what scientists are sayingThe Scientist Staff
- The Rap Guide to Evolution Ιουνίου 1, 2011Yo! Darwin!Richard P. Grant
- Arsenic-based life debate continues Ιουνίου 2, 2011More than a dozen researchers voice their concerns about a 2010 paper that claims bacteria can use arsenic in place of phosphorus in its DNA and other biomoleculesJessica P. Johnson
- The rhythm of biology Ιουνίου 3, 2011
Πρακτικά της Εθνικής Ακαδημίας Επιστημών » PNAS- In This Issue [This Week in PNAS]Extraterrestrial quasicrystalpnas;109/5/1355/UNFIG01F1unfig01Rock sample from the mineral collection of the Museo di Storia Naturale in Florence, previously unearthed in the Koryak Mountains in Russia.Unlike crystalline solids, quasicrystals contain a near-periodic arrangement of atoms and symmetries not normally found in crystals. Luca Bindi et al. (pp. 139 […]
- Femtosecond laser vaporization that preserves protein-folded structure: An unproven idea [Letters (Online Only)]Electrospray ionization (ESI) made the transfer of nonvolatile molecules, such as proteins, from solution into the gas phase without covalent bond dissociation possible, revolutionizing MS for biological applications. However, whether the gaseous ions from ESI can preserve their biologically active native structure for characterization by MS is still controv […]Breuker, K., Skinner, O. S., McLafferty, F. W.
- Reply to Breuker et al.: How laser electrospray mass spectrometry (LEMS) measures condensed phase protein structure, not vacuum structure [Letters (Online Only)]An important goal for the field of mass spectrometry is the development of methods capable of measuring biomolecular structure in the condensed phase. Recently, we reported a femtosecond laser vaporization method for transferring protein from the condensed phase into the gas phase intact, with electrospray postionization evidence that the folded conformation […]Brady, J. J., Judge, E. J., Levis, R. J.
- Are low-frequency songs sexually selected, and do they lose their potency in male-female interactions under noisy conditions? [Letters (Online Only)]We agree with Halfwerk et al. (1) on the importance of including the receivers when studying the impact of anthropogenic noise. However, we find the conclusion that the use of low-frequency song is sexually selected in great tits and that noisy conditions affect male–female communication premature for several reasons.First, the evidence that low-frequency so […]Eens, M., Rivera-Gutierrez, H. F., Pinxten, R.
- Reply to Eens et al.: Urban noise can alter sexual selection on bird song [Letters (Online Only)]Eens et al.(1) question (i) whether our data are sufficient to state that low-frequency songs are sexually selected and (ii) whether anthropogenic noise really affects male–female communication, as males may just get closer to make their songs more audible.In reply to the first criticism, we do not see any reason in their arguments that would raise doubts ab […]Halfwerk, W., Bot, S., Buikx, J., van der Velde, M., Komdeur, J., ten Cate, C., Slabbekoorn, H.
- In This Issue [This Week in PNAS]
Softpedia » Microbiology/Genetics- How DNA Is Damaged by Enzyme Errors Ιανουαρίου 31, 2012Some people are at higher risk of developing cancer as a result of DNA damage than others, and a team of investigators at the Massachusetts Institute of Technology (MIT) believes it may have just discovered the mechanism behind this connection. In the study, the group focused its attention on a class of molecules called purines. These biochemica...Softpedia News (Tudor Vieru)
- Excessive Iron Concentrations Lead to Neurodegenerative Dementias Ιανουαρίου 31, 2012University of Melbourne scientists, in Australia, say that excessive iron concentrations in the human brain may represent one of the main causes of neurodegenerative forms of dementia, such as Alzheimer's and Parkinson's diseases. This study is critical because the conditions are incurable. The thing about these for...Softpedia News (Tudor Vieru)
- New Class of Proteins Regulating the Hypoxic Response Found Ιανουαρίου 31, 2012A new class of proteins responsible for controlling the way in which the body responds to hypoxic situations (in which insufficient amounts of oxygen are available to conduct regular processes) has just been discovered by a collaboration of investigators in the United Kingdom. Experts at the University of Nottingham, the ...Softpedia News (Tudor Vieru)
- Circular Motion Responsible for Forming Acini in Breast Cells Ιανουαρίου 27, 2012Scientists with the US Department of Energy's (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab) announce the discovery of a new type of circular cellular motion, exhibited by cells in the breast tissue. This type of movement is apparently essential for forming acini. These are spherical structures that develop ...Softpedia News (Tudor Vieru)
- MSU Team Shows How Easily Viruses Mutate Ιανουαρίου 27, 2012In addition to being extremely dangerous to humans on their own, many microorganisms also display the ability to mutate extremely fast, so that they can adapt to new, unexpected situations at a moment's notice. The capability was observed as scientists monitored microbes in a new experiment. The research team, which is based at the Michigan...Softpedia News (Tudor Vieru)
- Simple Combo Reduces Spread of Flu Epidemics Ιανουαρίου 26, 2012University of Michigan (U-M) investigators determined in a new study that the spread of pandemic flu could be reduced by as much as 75 percent if people simply wash their hands and wear face masks. These two simple actions can deal a devastating blow to the pathogen, preventing it from spreading like wildfire among social circles. The r...Softpedia News (Tudor Vieru)
- First 3D Images Acquired of Individual Proteins Ιανουαρίου 25, 2012A group of experts at the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab) were recently able to produce the first 3D image of an individual protein ever obtained. This was made possible when scientists at the lab's Molecular Foundry pushed their Zeiss Libra 120 Cryo-Tem microscope far beyond the ...Softpedia News (Tudor Vieru)
- Why Bacterial Biofilms Spread Ιανουαρίου 25, 2012Investigators at the Harvard School of Engineering and Applied Sciences (SEAS) say that the structure of the extracellular matrix enveloping bacteria capable of producing biofilms is set up in such a way that it literally forces the microorganisms to swell, spread and expand their colonies. Biofilms are layers of proteins and lipids that bacteria colo...Softpedia News (Tudor Vieru)
- Lifetime Habits Prevent Alzheimer's Ιανουαρίου 24, 2012Reading, solving math problems, doing puzzles and many other activities that stimulate cognitive processes help prevent the development of a form of neurodegenerative dementia called Alzheimer's disease, researchers at the University of California in Berkeley (UCB) argue in a new study. Making a lifetime habit out of these activities helps the b...Softpedia News (Tudor Vieru)
- Experts Gain New Insight into How Aerobic Respiration Developed Ιανουαρίου 23, 2012For a very long time after the first lifeforms developed on Earth, the atmosphere was significantly different from the way it is today. Researchers have been trying to determine how things evolved over time, and a new study now helps shed some more light on the issue. Japanese investigators at the RIKEN Spring-8 Cente...Softpedia News (Tudor Vieru)
- How DNA Is Damaged by Enzyme Errors Ιανουαρίου 31, 2012







































